ncRNA name | RAGE siRNA |
ncRNA Category | siRNA |
Disease name | age-related macular degeneration (AMD) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | siRNA transfection, immunofluorescence staining, immunocytochemistry, Western blot, qPCR |
Expression pattern | associated |
Functional description | Receptor for advanced glycation end products (RAGE) contributed to endocytosis of Aβ in RPE. RAGE could be a potential therapeutic target for intracellular Aβ induced outer BRB breakdown in AMD. siRNA-mediated knockdown of RAGE prevented intracellular Aβ accumulation as well as subsequent tight junction breakdown in RPE. |
PubMed ID | 26431165 |
Year | 2015 |
Title | RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium. |
Drug-related ncRNA | NO |
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